A Combined Patient and Provider Intervention for Management of Osteoarthritis in Veterans A …

A Combined Patient and Provider Intervention for Management of Osteoarthritis in Veterans A …The particular provider input involved shipping of patient-specific osteoarthritis therapy recommendations to be able to primary attention providers …
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Caspase-1 mediated interleukin-18 activation in neutrophils promotes the activity of rheumatoid arthritis in a NLRP3 inflammasome independent manner.Caspase-1 mediated interleukin-18 activation in neutrophils promotes the activity of rheumatoid arthritis in a NLRP3 inflammasome independent manner.
Joint Bone Spine. 2016 Jan 5;
Authors: Yang Z, Cao J, Yu C, Yang Q, Zhang Y, Han L
Abstract
OBJECTIVES: To investigate the role of NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome in the peripheral neutrophils in rheumatoid arthritis (RA).
METHODS: RA patients (n=48) and healthy controls (n=41) were enrolled and blood samples were collected for analysis. Protein expression of NLRP3 inflammasome components was detected by Western blot. Messenger RNA expression of NLRP3 inflammasome was detected by quantitative real-time reverse transcription-PCR. Sera levels of interleukin-1 beta (IL-1β) and interleukin-18 (IL-18) were detected by enzyme-linked immunosorbent assay (ELISA). Correlations among NLRP3 inflammasome activation, sera cytokines and RA disease acSee Original Article

FDA approves secukinumab for psoriatic arthritisNovartis announced January 15 that the FDA approved Cosentyx (secukinumab) for psoriatic arthritis and active ankylosing spondylitis.
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